Xiaflex

Peyronie's Disease treatment

Peyronie's disease (PD) is a condition in which a buildup of fibrous scar tissue causes a curvature of the penis. This curvature can be painful during arousal and intimacy. PD can affect as many as 1 in 10 men in the U.S., but diagnosis rates remain low because men with PD may be too uncomfortable to speak up and get help.

Bent carrot 1 in 10 men peyronie's disease

XIAFLEX is a prescription medicine used to treat adult men with Peyronie's disease who have a "plaque" that can be felt and a curve in their penis greater than 30 degrees when treatment is started.

More than 38,000 men have been prescribed Xiaflex for PD.^†

^†As of May 2022. Source: Specialty Pharmacy transactions for men prescribed XIAFLEX for PD from January 1, 2014 to May 12, 2022. Data on File. DOF-XPD-30.

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What are the benefits of Xiaflex?

Reduce penile curvature

Proven to help gradually reduce penile curvature.

Outpatient procedure

Quick outpatient procedure done in office.

Nonsurgical option

Only FDA approved, nonsurgical option for Peyronie's disease.

Affordable

Co-pay program makes it little to no cost to patient.

FDA Approved

FDA approved treatment for Peyronie’s disease.

Targeted treatment

Targets the Peyronie’s plaque directly.

Clinically proven. Patient approved.

Xiaflex is the first and only FDA-approved nonsurgical treatment for PD. When paired with daily penile exercises, XIAFLEX has been proven to help reduce erectile curvature in appropriate men with PD.

IMPROVEMENT IN ERECTILE CURVATURE

Men who received XIAFLEX and performed daily gentle penile stretching and straightening activities had an average change in their erectile curvature with a treatment difference of 17% in study 1 and 11% in study 2 from the beginning of the studies to Week 52, compared to men who were treated with placebo (no medicine).

IMPROVEMENT IN BOTHER SCORE

The Bother domain score was measured at the beginning and end (52 weeks) of the studies. The Bother domain score is a total score from answers about the following items:

Concern about how their erection looks and about erection pain
Impact of Peyronie's disease on frequency of intercourse
Impact of Peyronie's disease on intercourse

Men who received XIAFLEX reported improvement in Bother score from the beginning of the study to Week 52 compared to placebo.

XIAFLEX was not associated with shortening of penile length in clinical trials in the treatment of Peyronie's disease.

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Is It Expensive?

Unfortunately, many people read some misleading costs published on the internet. Xiaflex can be very affordable. In fact,

~90% OF ELIGIBLE PATIENTS PAID $0 OUT OF POCKET WITH THE XIAFLEX COPAY ASSISTANCE PROGRAM^*

The XIAFLEX Copay Assistance Program can cover up to $1200 of your out-of-pocket costs for each vial of XIAFLEX (collagenase clostridium histolyticum). What you pay for XIAFLEX depends on your health benefits or insurance coverage. Call us directly at (708) 888-8287 to find out your estimated costs.

IF ELIGIBLE, YOU MAY PAY $0 OUT OF POCKET FOR XIAFLEX^*

Check your eligibility

You are eligible for assistance under this program if:

You are receiving or have received XIAFLEX for the approved indication and in a manner consistent with the instructions for administration of XIAFLEX
You are uninsured or have insurance that is not provided by Medicare, Medicare Prescription Drug Benefit plans, Medicare Advantage, Veterans Affairs (VA), Medicaid, or similar federal or state programs, and this program is not otherwise prohibited by law
You are 18 years of age or older
You have paid or are obligated to pay out-of-pocket costs for a prescription of XIAFLEX

No other purchase is necessary to receive this offer.

*Most eligible patients with commercial insurance plans paid $0 copay for XIAFLEX. Based on analysis of claims filed November 2017 through April 2020. Other restrictions, terms and conditions can be found here.

The Procedure

TREATMENT IS A TEAM EFFORT—INVOLVING BOTH YOU AND YOUR UROLOGIST

XIAFLEX^® injections work to help gradually break down your scar tissue (plaque) over 1 to 4 treatment cycles, with about 6 weeks in between. Your doctor will determine how many cycles you need.

A single treatment cycle has two parts:

PART ONE of XIAFLEX treatment is a series of in-office injections given by a trained urologist into the Peyronie's plaque (a bump of scar tissue under the skin of the penis).

PART TWO of XIAFLEX treatment involves gentle penile stretching and straightening activities that your doctor will perform in the office. You will also be expected to perform these exercises daily in the comfort and privacy of your home.

Is Xiaflex FDA Approved?

Is Xiaflex Safe?

Risks & Side Effects

Do not receive XIAFLEX if:

the Peyronie's plaque to be treated involves the "tube" that your urine passes through (urethra).
you are allergic to collagenase clostridium histolyticum or any of the ingredients in XIAFLEX, or to any other collagenase product. See the end of the Medication Guide for a complete list of ingredients in XIAFLEX.

XIAFLEX can cause serious side effects, including:

Penile fracture (corporal rupture) or other serious injury to the penis. Receiving an injection of XIAFLEX may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX, one of these tubes may break during an erection. This is called a corporal rupture or penile fracture. This could require surgery to fix the damaged area. Damage to your penis might not get better after a corporal rupture.
- After treatment with XIAFLEX, blood vessels in your penis may also break, causing blood to collect under the skin (hematoma). This could require a procedure to drain the blood from under the skin. If a hematoma appears, skin and soft tissue necrosis (death of skin cells) may develop in that area, which could require surgery.
Symptoms of corporal rupture or other serious injury to your penis may include:
- a popping sound or sensation in an erect penis
- sudden loss of the ability to maintain an erection
- pain in your penis
- purple bruising and swelling of your penis
- difficulty urinating or blood in the urine
Call your healthcare provider right away if you have any of the symptoms of corporal rupture or serious injury to the penis listed above.

Do not have sex or any other sexual activity between the first and second injections of a treatment cycle.

Do not have sex or have any other sexual activity for at least 4 weeks after the second injection of a treatment cycle with XIAFLEX and after any pain and swelling has gone away.

XIAFLEX for the treatment of Peyronie's disease is only available through a restricted program called the XIAFLEX Risk Evaluation and Mitigation Strategy (REMS) Program.
Hypersensitivity reactions, including anaphylaxis. Severe allergic reactions can happen in people who receive XIAFLEX, because it contains foreign proteins.

Call your healthcare provider right away if you have any of these symptoms of an allergic reaction after an injection of XIAFLEX:
- hives
- swollen face
- breathing trouble
- chest pain
- low blood pressure
- dizziness or fainting
Back pain reactions. After receiving an injection of XIAFLEX for Peyronie’s disease, you may suddenly feel back pain, including severe lower back pain moving to your legs, feet, chest and arms. The back pain may also include spasms and make it hard to walk. These symptoms usually go away in 15 minutes or less, but may last longer.
Tell your healthcare provider right away if you have sudden back pain, chest pain, or hard time walking after an injection.
Fainting. Fainting (passing out) or near fainting can happen in men who receive XIAFLEX, especially if they have severe penile pain.
If you have dizziness or feel faint after receiving XIAFLEX, lie down until the symptoms go away.

Before receiving XIAFLEX, tell your healthcare provider if you have had an allergic reaction to a previous XIAFLEX injection, have a bleeding problem, received XIAFLEX for another condition, or any other medical conditions. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Using XIAFLEX with certain other medicines can cause serious side effects. Especially tell your healthcare provider if you take medicines to thin your blood (anticoagulants). If you are told to stop taking a blood thinner before your XIAFLEX injection, your healthcare provider should tell you when to restart the blood thinner. Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure.

What should I avoid while receiving XIAFLEX?
Avoid situations that may cause you to strain your stomach (abdominal) muscles, such as straining during bowel movements.

Do not use a vacuum erection device during your treatment with XIAFLEX.

XIAFLEX can cause serious side effects, including increased chance of bleeding. Bleeding or bruising at the injection site can happen in people who receive XIAFLEX. Talk to your healthcare provider if you have a problem with your blood clotting. XIAFLEX may not be right for you.

The most common side effects with XIAFLEX for the treatment of Peyronie's disease include:

a small collection of blood under the skin at the injection site (hematoma)
swelling at the injection site or along your penis
pain or tenderness at the injection site, along your penis and above your penis
penis bruising
itching of your penis or scrotum (genitals)
painful erection
erection problems (erectile dysfunction)
changes in the color of the skin of your penis
blisters at the injection site
pain with sex
a lump at the injection site (nodule)

Tell your healthcare provider if you have any side effect that bothers you or does not go away.

These are not all of the possible side effects with XIAFLEX. For more information, ask your healthcare provider or pharmacist. You may report side effects to FDA at 1-800-FDA-1088.

Click for full Prescribing Information, including Boxed Warning and Medication Guide.

Who is a good candidate for Xiaflex?

Xiaflex is a treatment option for men who have both a bump of scar tissue that can be felt and a curved erection of at least 30 degrees. Schedule an appointment with your provider to discuss if Xiaflex is an appropriate treatment option for you.

15 degree peyronie's disease at assoicated urological specialists

30 degree peyronie's disease at assoicated urological specialists

60 degree peyronie's disease at assoicated urological specialists

We understand talking about this may be difficult or embarrassing

It shouldn't be. That is why we provide our own discreet channel for asking any questions you may have about the condition. Our team of patient navigators specialize in this area. Trust us when we say we have heard it all. So give us a call on this PD dedicated number and ask away.

(708) 761-9472

You can also submit the form below. Either way, you can be assured your conversations will be discreet and directly with one of our nurse navigators who understand PD.

Pyronie's disease is treatable & Xiaflex can be a good option.

Ready to take the first step? Schedule a consultation with your doctor to discuss your symptoms and to determine if Xiaflex therapy is right for you.

Make an Appointment Today

Call us today or use the button below to schedule an OAB appointment.

(708) 888-8AUS

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Dr. John DeFranco, Board-Certified Urologist at AUS.

Dr. John DeFranco is one of our board-certified urologists who has a specialized focus in Men's Health, particularly with Peyronie's Disease. Dr. DeFranco has some of the deepest experience and success treating PD throughout Chicagoland and Northwest Indiana.

Men's Health Appointments at AUS are in Chicago, Southside Chicago and Northwest Indiana.

Peyronie's disease testing, diagnosis and treatment can be performed quickly at any of our AUS offices. They are conveniently located in Chicago, Chicago Ridge, Evergreen Park, Homewood, Orland Park, IL and Highland, IN.

Xiaflex treatments for Peyronie's disease are done best with AUS.

Patients have learned the most advanced urology procedures, like Peyronie's disease treatments, are done at AUS. See us if you live in Alsip, Bedford Park, Blue Island, Bridgeview, Burbank, Calumet Park, Chicago Heights, Country Club Hills, Crestwood, Englewood, Glenwood, Harvey, Hickory Hills, Homer Glen, Matteson, Midlothian, Mokena, Oak Lawn, Oak Forest, Olympia Fields, Orland Hills, Park Forest, Roseland, South side, South Holland and Tinley Park. Patients treated successfully at AUS come from Bolingbrook, Brighten Park, Burnham, Burr Ridge, Calumet City, Countryside, Crystal Lawns, Crest Hill, Darien, Dolton, Fairmont, Frankfort, Gage Park, Gillets, Hammond, Hinsdale, Hyde Park, Ingalls Park, Lansing, Lynwood, La Grange, Lemont, Lockport, Munster, Palisades, Richton Park, Riverdale, Romeoville, Sauk Village, South Shore, South Chicago, Westmont, Whiting, Willowbrook and Woodridge.

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Xiaflex

Peyronie's Disease treatment

More than 38,000 men have been prescribed Xiaflex for PD.^†